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Cephalexin should be administered with caution in the presence of markedly impaired renal function. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk cephalexin online kjop of side effects. Therefore, you are recommended to stop nursing while taking cephalexin. Drug Interactions Metformin In healthy subjects given single 500 mg doses of Cephalexin and metformin, plasma metformin mean Cmax and AUC increased by an average of 34 and 24 respectively, and metformin mean renal clearance decreased by 14.